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1. The ability of the three nitrophenols, m-nitrophenol, p-nitrophenol and 2,4-dinitrophenol, to inhibit acid secretion and stimulate oxygen uptake by gastric mucosa paralleled their extent of dissociation at physiological pH.

2. Oligomycin inhibited oxygen uptake by gastric mucosa, and showed a tendency to inhibit acid secretion.

3. 2,4-dinitrophenol lowered the value of the ratio between acid secretion and the associated oxygen uptake. Oligomycin did not affect the value of this ratio.

4. It would appear that a non-phosphorylated high-energy intermediate of oxidative phosphorylation might be involved in acid secretion by gastric mucosa.

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				A. M. Cheng, S. W. Morrison, D. X. Yang, and S. J. Hagen Energy dependence of restitution in the gastric mucosa Am J Physiol Cell Physiol, August 1, 2001; 281(2): C430 - C438. [Abstract] [Full Text] [PDF]