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Charles Edwards, Hrvoje Lorkovi and Annemarie Weber

1. In frog skeletal muscle strontium can replace calcium in potassium contractures for 5 hr, though it is less effective than Ca. Sr can restore the responsiveness to K after it had been lost in the presence of Mn.

2. Muscles refractory to caffeine following repeated exposure to it in the absence of Ca, recover in part following addition of Sr.

3. The uptake of ⁸⁵Sr was increased during mechanical activity, whereas the uptake of ⁵⁸Co was not changed. Resting uptake of ⁵⁸Co was 3-4 times greater than that of ⁸⁵Sr.

4. Sr fully activated the myofibrillar adenosine triphosphatase (ATP-ase), though its affinity was about 30 times less than Ca.

5. The sarcoplasmic reticulum took up Sr, though less effectively than Ca.