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J Physiol Vol 187, Issue 1 pp 195-200
Copyright © 1966 by The Physiological Society
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The effect of amino acids on the intestinal transport of L- and D-xylose in vitro

H. L. Duthie and J. T. Hindmarsh

1. The intestinal transport of D-xylose by sacs of everted small intestine of the hamster is partially inhibited by L-histidine in concentrations of 5, 10 and 20 mM but not of 2 mM.

2. 20 mM concentrations of D-histidine and L-methionine also produce inhibition.

3. The inhibition is not due to an alteration in water transport or to a change in pH of the incubating medium.

4. The rate of the intestinal transport of L-xylose is about 1/4 of the rate of D-xylose transport and is unaffected by a 20 mM concentration of L-histidine.







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