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1. The effect of semistarvation (sufficient to produce a loss of 18-28% of initial body weight) on the active transport of D-glucose and L-histidine by the rat, the guinea-pig and the golden hamster has been investigated by the use of sacs of everted small intestine (from upper jejunum to lower ileum).

2. In the rat and the guinea-pig the dietary restriction resulted in increased active transport in all regions of the small intestine. In contrast, it caused no alteration in active transport in the hamster.

3. The response in the rat was most impressive in the middle-to-lower ileum during D-glucose uptake. Whereas normal sacs from this area appeared unable to move the sugar against its concentration gradient, sacs from semistarved rats did so quite well.

4. Although there was a considerable loss (24-29%) of intestinal dry weight in all three species when the food intake was reduced, shortening of the small intestine was not detectable in the guinea-pig or the hamster and was present to only a minor extent in the rat.

5. Evidence is presented indicating that the enhanced active transport is not merely a reflexion of the thinning of the intestinal wall and that it occurs during complete as well as in partial starvation.