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1. Basal O2 consumption and plasma free fatty acid (FFA) concentration were measured in normal and hypothyroid rats at various intervals after the initiation of a course of treatment with thyroid hormones.
2. A significant rise in basal O2 consumption was detectable in both groups of rats before there was any change in plasma FFA level.
3. It is concluded that the stimulatory effect of thyroid hormones on the basal O2 consumption of the whole animal is not mediated entirely by a rise in plasma FFA level.
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