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1. The relation between water loading and electrolyte excretion in dogs fed on a meat diet proved impossible to evaluate owing to the large variability in electrolyte excretion rates in control experiments.

2. In animals fed a synthetic diet of constant and known composition the administration of a water load of 2·5% of body weight caused significant increases in the rate of excretion of sodium (P < 0·01) and potassium (P < 0·05). The chloride excretion rate also increased in the one animal tested.

3. The significance of these results is discussed.