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1. The membrane conductance of the crayfish muscle fibre was calculated and the increase in the membrane conductance brought about by the application of -aminobutyric acid (GABA) was investigated under various conditions. The permeability of the activated inhibitory post-synaptic membrane was estimated from the conductance change.

2. When the concentration of Cl^- was changed by substituting Cl^- with methylsulphate, a linear relation was obtained between the membrane conductance change produced by GABA and the concentration of Cl^-. Cations have no appreciable effect on the GABA induced conductance change (less than 0·4%).

3. The conductance change produced by GABA on the inhibitory post-synaptic membrane was measured in various solutions in which the Cl^- was replaced by various anions. The degree of permeability depended on the anion species in the following order:

Br^- > Cl^- > SCN^- > I^- > NO₃^- > HCOO^- > ClO₃^- > ClO₄^- > BrO₃^-

4. At high pH the conductance change produced by GABA was decreased, while at low pH it increased.

5. These results show that the activated inhibitory post-synaptic membrane of crayfish muscle fibres has the characteristics of an anion selective membrane, suggesting the fixed positive charges in the inhibitory membrane.

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