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1. Changes in temperature were determined following injection of noradrenaline, adrenaline, isoprenaline, dopamine and 5-hydroxytryptamine (5-HT) into the cerebral ventricles of the conscious mouse.

2. Noradrenaline (1-20 µg) and dopamine (10-160 µg) caused falls in body temperature. Adrenaline (1-20 µg) caused a slight and transient rise in body temperature followed by a fall. Isoprenaline (5-20 µg) caused a rise in body temperature, hypothermia only occurring after very high doses (200 µg) of this catecholamine.

3. - and -adrenergic blocking agents, phentolamine (> 2 µg) and propranolol (> 5 µg) respectively, caused falls in body temperature when injected into the cerebral ventricles of the mouse.

4. Specific drug antagonism studies were limited owing to the intrinsic effects of the - and -adrenergic blocking agents. However, some evidence was obtained to indicate that noradrenaline mediated its effects through a central -type adrenergic receptor.

5. 5-HT (10-160 µg) caused a fall in body temperature. The action of this indoleamine and the catecholamines in regard to thermoregulatory function is discussed.

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