HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lockett, M. F. Search for Related Content PubMed PubMed Citation Articles by Lockett, M. F.

1. The effects of change in arterial P_O2, P_CO2 and pH on the total vascular resistance (RVR) of the perfused cat kidney have been separately measured and expressed as ± percentage deviations from control values.

2. Control levels in arterial blood were pH 7.38, P^-_O2 160 mm Hg, in equilibrium with 5% CO₂.

3. Increase in P_O2 alone, in excess of 220 mm Hg, raised RVR reversibly reading 108% control levels at a P_O2 280 mm Hg (P = < 0.001).

4. High levels of P_O2 favoured the onset of `outflow block', which was characterized by irreversible increase in RVR accompanied by rise in plasma filtration fraction (F.F.) and in the extraction ratio for p-aminohippuric acid (PAH extraction).

5. Reduction in P_O2 to 80 mm Hg decreased RVR by 4% (P = < 0.001).

6. RVR was not significantly affected by pH changes within the range 7.25-7.45. Lowering arterial pH to 7.15 raised RVR by 4% (P = < 0.001) reversibly. Increase in arterial pH to 7.56 raised RVR by 6% (P = < 0.001) reversibly.

7. Changes in arterial P_CO2 produced large inverse reversible changes in RVR. Halving P_CO2 raised RVR by 18%; doubling P_CO2 decreased RVR by 25%.

8. Changes in RVR caused by alteration of arterial pH or P_CO2 were not accompanied by changes either in F.F. or in PAH extraction.

This article has been cited by other articles:

				T. V. Keaveny, J. P. Pryor, C. White, and F. O. Belzer Renal Vasomotor Responses in the Agonal Period Angiology, February 1, 1971; 22(2): 77 - 85. [PDF]