HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Armstrong, D. M. Articles by Harvey, R. J. Search for Related Content PubMed PubMed Citation Articles by Armstrong, D. M. Articles by Harvey, R. J.

1. Surface potentials, similar to those found by earlier workers, have been recorded from the vermis of the anterior lobe of the cerebellum following stimulation of muscular, cutaneous and articular nerves of the ipsilateral hind limb. The most conspicuous component of the response consisted of a positive potential succeeded by a smaller negative potential.

2. Micro-electrode recordings showed that this component coincided both with climbing fibre responses in individual Purkinje cells, and with extracellular field potentials within the cerebellar cortex which closely resembled those found by Eccles, Llinás & Sasaki (1966) following electrical stimulation of the inferior olive.

3. Stimulation of the cerebellar surface, in the region where the responses to limb nerve stimulation were largest, led to antidromic invasion of neurones of the contralateral inferior olive. The antidromic action potentials were sometimes followed by up to three orthodromic spikes. Histological techniques were used to show that these neurones were located in the caudal parts of the dorsal and medial accessory olives.

4. Stimulation of nerves of the hind limb evoked discharges of the same neurones of the dorsal accessory olive which were antidromically invaded from the vermis of the anterior lobe. The nerves used (quadriceps, gastrocnemius-soleus, sural and the posterior nerve to the knee joint) were shown to excite heavily overlapping populations of neurones.

5. Those neurones of the medial accessory olive, which were identified antidromically from the anterior lobe vermis, were not discharged by stimulation of hind limb nerves.

6. Simultaneous recording from the surface of the anterior lobe and from the dorsal accessory olive showed that the onset of olive cell discharges occurred about 5 msec before the onset of the positive potential at the cerebellar surface.

This article has been cited by other articles:

				R. Ackerley, J. Pardoe, and R. Apps A novel site of synaptic relay for climbing fibre pathways relaying signals from the motor cortex to the cerebellar cortical C1 zone J. Physiol., October 15, 2006; 576(2): 503 - 518. [Abstract] [Full Text] [PDF]

				M. R. Baker and S. A. Edgley Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum J. Physiol., February 1, 2006; 570(3): 501 - 506. [Abstract] [Full Text] [PDF]

				N. L. Cerminara and J. A. Rawson Evidence that Climbing Fibers Control an Intrinsic Spike Generator in Cerebellar Purkinje Cells J. Neurosci., May 12, 2004; 24(19): 4510 - 4517. [Abstract] [Full Text] [PDF]

				J. Pardoe, S. A. Edgley, T. Drew, and R. Apps Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion J. Neurosci., March 17, 2004; 24(11): 2656 - 2666. [Abstract] [Full Text] [PDF]

				D. A. Nicholson and J. H. Freeman Jr Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Inferior Olive J. Neurosci., November 1, 2000; 20(21): 8218 - 8226. [Abstract] [Full Text] [PDF]