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1. Ethacrynic acid (10^-3 M) at pH 7·4 caused approximately 83% inhibition of Na efflux from single dissected toad oocytes.

2. Less inhibition was found at concentrations below 10^-3 M but higher concentrations did not cause greater inhibition.

3. At an external pH of 7·0 the onset of inhibition was more rapid than at pH 7·4.

4. Ouabain (10^-3 M) produced only 30% inhibition of the Na efflux, and the subsequent application of ethacrynic acid largely inhibited the remaining efflux.

5. Application of ouabain, after ethacrynic acid had produced some 80% inhibition, caused only a further 9% drop in efflux.

6. In uninhibited cells, Na efflux was found to be greater at pH 8·0, and less at pH 7·0 than at 7·4.