| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1. Experiments were performed on foetal lambs at gestations between 125 days and term. The foetus was exteriorized at Caesarean section with the umbilical cord and placental attachment maintained intact. Samples of liquid from the alveolar parts of the lung were withdrawn through a tracheal cannula and samples of lung lymph, plasma and amniotic liquid were also obtained. Measurements were made of total osmolality, concentrations of electrolytes and urea, pH and PCO2. Titrations were carried out with N/10 HCl and N/10 NaOH. The water content of the liquids was estimated and concentrations expressed per kg H2O.
2. In alveolar liquid [H+], [K+] and [Cl-] were higher and [Ca2+], [phosphates] and [HCO3-] were lower than in plasma or lymph. In amniotic liquid osmolality [Na+], [Cl-] and [Ca2+] were lower and [phosphates] higher than in plasma or lymph. Alveolar liquid/plasma ratios of [HCO3-], [Ca2+], [Cl-] and [K+] differed from ultra filtrate/plasma ratios of these ions.
3. Titration curves demonstrated a very small amount of buffering in alveolar liquid at its in vivo pH of 6·27 mostly due to HCO3- at an average concentration of 2·8 mM/kg H2O.
4. It is concluded that foetal alveolar liquid is not an ultrafiltrate of plasma nor a mixture of amniotic liquid and plasma ultrafiltrate, but a special material elaborated by the foetal lung.
This article has been cited by other articles:
|
|
 |
|
  H. O'Brodovich, P. Yang, S. Gandhi, and G. Otulakowski Amiloride-insensitive Na+ and fluid absorption in the mammalian distal lung Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L401 - L408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Elias and H. O'Brodovich Clearance of Fluid From Airspaces of Newborns and Infants NeoReviews, February 1, 2006; 7(2): e88 - e94. [Full Text] [PDF]
|
|
|
|
|
|
R. D. Bland Lung Fluid Balance During Development NeoReviews, June 1, 2005; 6(6): e255 - e267. [Full Text] [PDF]
|
|
|
|
|
|
R. Murphy, V. V. Cherny, D. Morgan, and T. E. DeCoursey Voltage-gated proton channels help regulate pHi in rat alveolar epithelium Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L398 - L408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Blaisdell, M. M. Morales, A. C. O. Andrade, P. Bamford, M. Wasicko, and P. Welling Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung cysts Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L420 - L426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Effros, L. Olson, W. Lin, S. Audi, G. Hogan, R. Shaker, K. Hoagland, and B. Foss Resistance of the pulmonary epithelium to movement of buffer ions Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L476 - L483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Hyde ""I Don't Know What You Guys Are Measuring But You Sure Are Measuring It!"" . A Fair Criticism of Measurements of Exhaled Condensates? Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 561 - 562. [Full Text] [PDF]
|
|
|
|
|
|
R. M. EFFROS, K. W. HOAGLAND, M. BOSBOUS, D. CASTILLO, B. FOSS, M. DUNNING, M. GARE, W. LIN, and F. SUN Dilution of Respiratory Solutes in Exhaled Condensates Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 663 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. O'Brodovich Fetal Lung Liquid Secretion . Insights Using the Tools of Inhibitors and Genetic Knock-out Experiments Am. J. Respir. Cell Mol. Biol., July 1, 2001; 25(1): 8 - 10. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Blaisdell, R. D. Edmonds, X.-T. Wang, S. Guggino, and P. L. Zeitlin pH-regulated chloride secretion in fetal lung epithelia Am J Physiol Lung Cell Mol Physiol, June 1, 2000; 278(6): L1248 - L1255. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
