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J Physiol Vol 204, Issue 1 pp 51-61
Copyright © 1969 by The Physiological Society
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The effects of alloxan and histamine on the permeability of the pulmonary alveolocapillary barrier to albumin

 Boyd W. Goetzman and Maurice B. Visscher

1. [131I]albumin transport from alveolus to perfusion fluid was evaluated in an isolated dog lung lobe preparation perfused at constant pressure with homologous plasma. The alveoli were filled with a 1:1 mixture of Ringer—Tyrode solution and plasma.

2. For twenty-three lung lobes, an average control permeability coefficient of the alveolocapillary membrane for albumin was found to be 1·9 x 10-9 cm/sec with a range of (0·3-5·5) x 10-9 cm/sec.

3. Alloxan in concentrations of 0·22-2·50 mg/ml. perfusate was observed to increase the alveolocapillary membrane permeability to [131I]albumin with a positive correlation between dose and effect. The larger doses of alloxan increased the permeability by a factor of ten or more.

4. Glutathione (GSH), administered intravascularly 2 min before alloxan in an 8:1 molar ratio of GSH:alloxan, delayed the onset of the permeability increase due to alloxan by 40-60 min but did not influence the maximum increase in permeability.

5. Histamine administered intravascularly in concentrations from 0·02 to 0·50 µg/ml. perfusate had no significant effect on the alveolocapillary membrane permeability to [131I]albumin.




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K.-J. Kim, Y. Matsukawa, H. Yamahara, V. K. Kalra, V. H. L. Lee, and E. D. Crandall
Absorption of intact albumin across rat alveolar epithelial cell monolayers
Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L458 - L465.
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