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J Physiol Vol 210, Issue 2 pp 421-432
Copyright © 1970 by The Physiological Society
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Properties of kallikrein-containing granules isolated from the submaxillary gland of the guinea-pig

 K. D. Bhoola and P. F. Heap

1. Granular fractions of high purity consisting of subcellular kallikrein- and amylase-storing organelles have been isolated from homogenates of guinea-pig submaxillary gland.

2. The isolated kallikrein- and amylase-containing granules closely resembled secretory granules observed in situ in serous acinar cells in intra-granular appearance, size and histochemical reaction.

3. The subcellular, histochemical and ultrastructural studies indicate that the serine protease, kallikrein, is like amylase an exocrine enzyme with a functional role in saliva.






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