HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Band, D. M. Articles by Semple, S. J. G. Search for Related Content PubMed PubMed Citation Articles by Band, D. M. Articles by Semple, S. J. G.

1. An in vivo pH monitoring technique was used to assess changes in pH, and by inference changes in P_CO2, in the carotid artery of anaesthetized cats. The changes in carotid artery pH and respiration following abrupt injections of various acids into the carotid artery or aorta were investigated.

2. Injections of saline equilibrated with 100% CO₂, timed to produce changes at the carotid body chemoreceptors during early inspiration caused an increase in the tidal volume of that breath. The amplitude and rate of change of the pH changes so produced were comparable with those of the oscillations in pH produced by respiration itself.

3. The respiratory responses to injection of saline equilibrated with 100% CO₂ occurred whether the animal was breathing air or 100% O₂.

4. Injections of lactic or hydrochloric acid were without an effect on respiration, except when pH changes larger than 0·1 pH unit were produced. A NaHCO₃ solution equilibrated with 30% CO₂ stimulated respiration, even though the solution was alkaline to the cat's arterial blood and induced an alkaline change in arterial pH.

5. Infiltration of the carotid sinus nerve area with procaine temporarily abolished the respiratory response to injections of saline equilibrated with 100% CO₂.

This article has been cited by other articles:

				D. J. Collier, A. H. Nickol, J. S. Milledge, H. J. A. van Ruiten, C. J. Collier, E. R. Swenson, A. Datta, and C. B. Wolff Alveolar PCO2 oscillations and ventilation at sea level and at high altitude J Appl Physiol, February 1, 2008; 104(2): 404 - 415. [Abstract] [Full Text] [PDF]