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1. The blocking action of adrenaline on the superior cervical ganglion of the rabbit was investigated with intracellular recording techniques.

2. Adrenaline (10^-5 M) blocked initiation of post-synaptic action potentials and decreased the amplitude of excitatory post-synaptic potentials (e.p.s.p.s), but did not hyperpolarize the post-synaptic membrane.

3. The depressant action of adrenaline was antagonized by phenoxy-benzamine and dihydroergotamine.

4. Acetylcholine depolarizations from iontophoretic ACh were not affected by adrenaline.

5. Adrenaline decreased the frequency of miniature excitatory post-synaptic potentials (m.e.p.s.p.s) and decreased the quantal content of e.p.s.p.s in a low [Ca²⁺]: [Mg²⁺] media.

6. It was concluded that adrenaline blocks ganglionic transmission by acting at an alpha-adrenoceptive site in the presynaptic nerve terminals.

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				S.-D. Liang and E. S. Vizi Positive Feedback Modulation of Acetylcholine Release from Isolated Rat Superior Cervical Ganglion J. Pharmacol. Exp. Ther., February 1, 1997; 280(2): 650 - 655. [Abstract] [Full Text]