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1. Using a ventilated capsule in conjunction with an infra-red water vapour analyser, and an indwelling intradermal needle, quantitative studies were made relating the magnitude of the sweat responses to the doses of acetylcholine or methacholine.

2. Acetylcholine dose—response curves were constructed, and from these curves the threshold dose was defined. The threshold was similar in all subjects (10^-3 ± S.E. 10^-4 µg/0·1 ml.).

3. Factors affecting the acetylcholine dose—response curves were studied. Optimum conditions for stimulation in all subjects occurred using a capsule of 0·63 cm diameter, injection volume of 0·1 ml. and a solution temperature of 37° C. When the skin temperature was 36° C the maximal acetylcholine response was then the same as the maximal thermal response.

4. No change in the acetylcholine dose—response curves occurred with repeated determinations at the same site on the same occasion.

5. The dose—response relationship for methacholine was similar to that for acetylcholine. The methacholine response was, however, more prolonged and so the volumes secreted were greater.

This article has been cited by other articles:

				K. Kimura, D. A. Low, D. M. Keller, S. L. Davis, and C. G. Crandall Cutaneous blood flow and sweat rate responses to exogenous administration of acetylcholine and methacholine J Appl Physiol, May 1, 2007; 102(5): 1856 - 1861. [Abstract] [Full Text] [PDF]