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1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium.
2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual end-plates, studied with intracellular electrodes, was measured.
3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.
4. The mean quantum content (m) showed a positive correlation with the size of end-plates.
5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.
6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.
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