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1. The chloride content and fluxes, and the membrane potential of L cells have been measured.

2. L cells contain chloride, 70 m-mole/l. intracellular water and have a flux of 5·5 p-mole/cm² sec.

3. The membrane potential is -15 mV.K-free Krebs causes an increase in E_m and replacing chloride with sulphate causes a temporary reduction in E_m.

4. These values for E_m and chloride, and previously obtained values for Na and K fluxes and contents were used to calculate the permeabilities of the various ions using the Goldman constant field theory. This gave permeabilities of 6·3, 4·2 and 51 x 10^-9 cm/sec for K, Na and chloride respectively, a ratio of 1:0·67:8·10.

5. It is concluded that these cells have a low membrane potential because the P_K is some 100 times lower than in skeletal muscle, therefore leading to a P_K of the same order as P_Na.