J Physiol Wellcome Trust-funded researchers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 219, Issue 3 pp 739-745
Copyright © 1971 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feldberg, W.
Right arrow Articles by Saxena, P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feldberg, W.
Right arrow Articles by Saxena, P. N.

Further studies on prostaglandin E1 fever in cats

 W. Feldberg and P. N. Saxena

1. Micro-injections of a few nanograms of prostaglandin E1 (PGE1) into the anterior hypothalamus of unanaesthetized cats produced a rise in rectal temperature, whereas temperature was not affected when micro-injections of even larger doses were made into the posterior hypothalamus. The hyperthermia produced by injections of PGE1 into the cerebral ventricles is therefore attributed to an action of PGE1 on the anterior hypothalamus.

2. During a pentobarbitone sodium anaesthesia the sensitivity of cats to the hyperthermic effect of PGE1 injected into the cerebral ventricles was found to be greatly reduced, particularly during the early stage of anaesthesia when body temperature was falling steeply.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Matsumura, T. Shibakusa, T. Fujikawa, H. Yamada, K. Matsumura, K. Inoue, and T. Fushiki
Intracisternal administration of transforming growth factor- evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R266 - R275.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Nakamura, K. Matsumura, T. Hubschle, Y. Nakamura, H. Hioki, F. Fujiyama, Z. Boldogkoi, M. Konig, H.-J. Thiel, R. Gerstberger, et al.
Identification of Sympathetic Premotor Neurons in Medullary Raphe Regions Mediating Fever and Other Thermoregulatory Functions
J. Neurosci., June 9, 2004; 24(23): 5370 - 5380.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. V. Tabarean, M. M. Behrens, T. Bartfai, and H. Korn
Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition
PNAS, February 24, 2004; 101(8): 2590 - 2595.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. J. Madden and S. F. Morrison
Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R320 - R325.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Nakamura, K. Matsumura, T. Kaneko, S. Kobayashi, H. Katoh, and M. Negishi
The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area
J. Neurosci., June 1, 2002; 22(11): 4600 - 4610.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. E. Scammell, J. K. Elmquist, J. D. Griffin, and C. B. Saper
Ventromedial Preoptic Prostaglandin E2 Activates Fever-Producing Autonomic Pathways
J. Neurosci., October 1, 1996; 16(19): 6246 - 6254.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1971 The Physiological Society.