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1. End-plate currents have been studied in glycerol-treated frog sartorius nerve—muscle preparations with the voltage clamp technique.
2. End-plate currents follow a simple exponential time course over most of their declining phase.
3. The rate constant 
that characterizes this exponential decay depends upon membrane potential V according to the relationship (V) = BeAV, with A = 0·00795 ± 0·00043 (S.E.) mV-1 and B = 1·67 ± 0·04 (S.E.) msec-1.
4. Voltage sensitivity decreases (that is, A in the above equation becomes smaller) as the recording and current-passing electrodes are moved away from the end-plate region.
5. The voltage sensitivity of is decreased by decreasing the gain of the voltage clamp amplifier.
6. Changing the end-plate current amplitude by curare treatment, by increased calcium ion concentration, and by facilitation and depression has essentially no effect on end-plate current time course.
7. When membrane potential is changed step-wise during the decaying phase of the end-plate conductance change, currents begin to decline with a rate constant appropriate to the new membrane potential in less than 0·2 msec.
8. Treatment with prostigmine methylsulphate in concentrations up to 50 µg/ml. slows end-plate current decay but has little effect on voltage sensitivity. That is, B in the above equation is decreased by prostigmine treatment, but A is relatively unaffected.
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