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1. Intracellular records from Aplysia giant (R2) cell somata showed long lasting 4-10 mV hyperpolarizations after passage of outward current through a second intracellular electrode.

2. An increase in membrane slope conductance occurred simultaneously with the post-stimulus hyperpolarization (PSH).

3. Both the PSH and conductance-increase varied strongly with stimulus amplitude and duration.

4. Both the PSH and the conductance increase occurred in Ca-free medium containing tetrodotoxin, when action-potential production was completely blocked.

5. The PSH persisted in the presence of ouabain or DNP, with cooling, with removal of external K⁺, and in media where all the Na⁺ was replaced with Li⁺, suggesting that it was not due to the activity of an electrogenic pump.

6. A reversal potential for the PSH was demonstrated by application of maintained inward current following the end of an outward-directed stimulus.

7. The PSH reversal potential varied with [K]_o, but not with [Cl]_o or [Na]_o, suggesting that the PSH was mainly due to an increase in K conductance.

8. The PSH and the conductance increase were reduced strongly when all the Na⁺ was replaced with Tris, and only slightly when Na⁺ was replaced with sucrose.

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