| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1. The effects of anaesthetics (pentobarbitone, hexobarbitone, halothane, urethane, chloralose, chloral hydrate and ethanol) on the extracellular field potentials of the olfactory bulb produced by lateral olfactory tract stimulation were analysed.
2. Relatively large doses of all the anaesthetics (e.g. pentobarbitone, 40-70 mg/kg) depressed the synaptic excitation of granule cells.
3. The antidromic invasion of mitral cell dendrites was only slightly less sensitive to the anaesthetics than was the synaptic excitation of granule cells.
4. A wide dose range of anaesthetics (e.g. pentobarbitone, 3-60 mg/kg) prolonged the granule cell post-synaptic inhibition of mitral cells. All the anaesthetics, except ethanol, prolonged the inhibition.
5. The action of anaesthetics on post-synaptic inhibition was due to a specific effect on the inhibitory synapses.
6. Amino-oxyacetic acid, an inhibitor of GABA catabolism, had little effect on the synaptic inhibition or on the ability of hexobarbital to prolong the inhibition. This suggests that the prolongation seen with anaesthetics is not a result of interfering with GABA catabolism.
7. The present results are compared with results obtained with anaesthetics in other areas of the nervous system and it is proposed that prolongation of `gaba-ergic' inhibition might contribute to an agent's ability to produce general anaesthesia.
This article has been cited by other articles:
|
|
 |
|
  D. Rinberg, A. Koulakov, and A. Gelperin Sparse odor coding in awake behaving mice. J. Neurosci., August 23, 2006; 26(34): 8857 - 8865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Lukatch, C. E. Kiddoo, and M. B. MacIver Anesthetic-induced Burst Suppression EEG Activity Requires Glutamate-mediated Excitatory Synaptic Transmission Cereb Cortex, September 1, 2005; 15(9): 1322 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Sonner, M. Cascio, Y. Xing, M. S. Fanselow, J. E. Kralic, A. L. Morrow, E. R. Korpi, S. Hardy, B. Sloat, E. I. Eger II, et al. {alpha}1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear Mol. Pharmacol., July 1, 2005; 68(1): 61 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Friedman and B. W. Strowbridge Both Electrical and Chemical Synapses Mediate Fast Network Oscillations in the Olfactory Bulb J Neurophysiol, May 1, 2003; 89(5): 2601 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Richards Anaesthetic modulation of synaptic transmission in the mammalian CNS Br. J. Anaesth., July 1, 2002; 89(1): 79 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishikawa and M. B. MacIver Membrane and Synaptic Actions of Halothane on Rat Hippocampal Pyramidal Neurons and Inhibitory Interneurons J. Neurosci., August 15, 2000; 20(16): 5915 - 5923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Amin A Single Hydrophobic Residue Confers Barbiturate Sensitivity to gamma -Aminobutyric Acid Type C Receptor Mol. Pharmacol., March 1, 1999; 55(3): 411 - 423. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Wakasugi, K. Hirota, S. H. Roth, and Y. Ito The Effects of General Anesthetics on Excitatory and Inhibitory Synaptic Transmission in Area CA1 of the Rat Hippocampus In Vitro Anesth. Analg., March 1, 1999; 88(3): 676 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Antkowiak and D. Heck Effects of the Volatile Anesthetic Enflurane on Spontaneous Discharge Rate and GABAA-Mediated Inhibition of Purkinje Cells in Rat Cerebellar Slices J Neurophysiol, May 1, 1997; 77(5): 2525 - 2538. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
