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I. The effects of prostigmine and of the ratio of Mg²⁺ to Ca²⁺

M. Korda

I. Gabrovec, M. Korda and B. Popovi

1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end-plate current.

2. The end-plate current was measured by `clamping' the membrane potential during neuromuscular transmission.

3. The falling phase of the end-plate current was found to consist of a non-exponential, and an exponential portion, the duration of both of which varies under different experimental conditions.

4. The results suggest that the rate constants determining the dissociation of the receptor—mediator complex seem greatly to influence the time course of the end-plate current.