HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koles, Z. J. Articles by Rasminsky, M. Search for Related Content PubMed PubMed Citation Articles by Koles, Z. J. Articles by Rasminsky, M.

1. The theoretical effects of demyelination on conduction of a propagated impulse have been examined in a computer simulated myelinated nerve fibre. Demyelination was simulated by increasing the capacitance and conductance of the myelin sheath of individual internodes or parts of internodes.

2. Internodal conduction time increased as myelin thickness was decreased. The increase in internodal conduction time became more precipitous as the myelin became thinner. Propagation continued past a single demyelinated internode until myelin thickness was uniformly reduced to less than 2·7% of normal myelin thickness.

3. Paranodal demyelination was more effective in slowing impulse conduction than was uniform demyelination of an entire internode with an equivalent rise in overall internodal capacitance and conductance.

4. The effects on conduction of demyelination of two adjacent internodes or of two internodes separated by a normal internode were more than the sum of the effects of demyelination of each internode individually.

5. Propagation across a severely demyelinated internode was blocked with an increase in internal sodium concentration which had a trivial effect on conduction in a normal fibre.

6. Propagation across a severely demyelinated internode was blocked with increased temperature at a temperature at which propagation proceeds normally across normal internodes.

7. The similarity between the findings of the computer simulations and the experimental findings in demyelinated fibres is discussed.

This article has been cited by other articles:

				H. Bostock, M. Campero, J. Serra, and J. L. Ochoa Temperature-dependent double spikes in C-nociceptors of neuropathic pain patients Brain, September 1, 2005; 128(9): 2154 - 2163. [Abstract] [Full Text] [PDF]

				M. Vollmer, P. A. Leake, R. E. Beitel, S. J. Rebscher, and R. L. Snyder Degradation of Temporal Resolution in the Auditory Midbrain After Prolonged Deafness Is Reversed by Electrical Stimulation of the Cochlea J Neurophysiol, June 1, 2005; 93(6): 3339 - 3355. [Abstract] [Full Text] [PDF]

				C. Southwood, C. He, J. Garbern, J. Kamholz, E. Arroyo, and A. Gow CNS Myelin Paranodes Require Nkx6-2 Homeoprotein Transcriptional Activity for Normal Structure J. Neurosci., December 15, 2004; 24(50): 11215 - 11225. [Abstract] [Full Text] [PDF]

				R. K. Shepherd, J. H. Baxi, and N. A. Hardie Response of Inferior Colliculus Neurons to Electrical Stimulation of the Auditory Nerve in Neonatally Deafened Cats J Neurophysiol, September 1, 1999; 82(3): 1363 - 1380. [Abstract] [Full Text] [PDF]

				P. A. Felts, T. A. Baker, and K. J. Smith Conduction in Segmentally Demyelinated Mammalian Central Axons J. Neurosci., October 1, 1997; 17(19): 7267 - 7277. [Abstract] [Full Text] [PDF]

				O. Honmou, P. A. Felts, S. G. Waxman, and J. D. Kocsis Restoration of Normal Conduction Properties in Demyelinated Spinal Cord Axons in the Adult Rat by Transplantation of Exogenous Schwann Cells J. Neurosci., May 15, 1996; 16(10): 3199 - 3208. [Abstract] [Full Text] [PDF]