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J Physiol Vol 229, Issue 2 pp 339-348
Copyright © 1973 by The Physiological Society
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Spontaneous activity in isolated bovine mesenteric lymphatics

H. J. D. Mawhinney and I. C. Roddie

1. Longitudinal tension was measured in isolated segments (approximately 20 mm in length and 2 mm in diameter) of bovine mesenteric lymphatic vessels.

2. Seventeen out of thirty-nine vessels showed regular spontaneous rhythmic contractions, the most common frequency being about 2/min.

3. The strength of each contraction was related to the duration of the preceding pause, a longer pause being associated with a stronger contraction.

4. Noradrenaline increased the frequency and decreased the amplitude of the contractions. This effect was abolished by {alpha}-receptor blockade with phentolamine.

5. Isoprenaline slowed the frequency of the contractions. This effect was abolished by beta-receptor blockade with propranolol.

6. Acetylcholine had little effect on the rate of spontaneous contractions.







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