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1. End-plate depolarization and associated `membrane noise' due to decamethonium, acetylthiocholine and suberyldicholine have been examined and compared with the effects of acetylcholine and carbachol.

2. The transient ionic channels resulting from the action of decamethonium and acetylthiocholine are of much shorter duration than those produced by acetylcholine. They are, therefore, similarly to carbachol channels, less effective in causing membrane depolarization.

3. Suberyldicholine, on the other hand, produces ion channels whose duration exceeds that of acetylcholine.

4. Lowering the temperature causes an increase in amplitude of the elementary potential change produced by decamethonium and acetylthiocholine.

5. The relation between the characteristic features of drug-induced membrane noise and the underlying molecular reaction rates is discussed.