J Physiol Society Meetings
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


J Physiol Vol 235, Issue 1 pp 103-131
Copyright © 1973 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adrian, R. H.
Right arrow Articles by Peachey, L. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adrian, R. H.
Right arrow Articles by Peachey, L. D.

Reconstruction of the action potential of frog sartorius muscle

R. H. Adrian and L. D. Peachey

1. Propagated action potentials of striated muscle are calculated using an equivalent circuit that represents the transverse tubular system as a radial cable of sixteen elements. The membrane of the transverse tubules is assumed to have activatable ionic currents similar to those in the fibre surface.

2. The configuration of the after-potential and the conduction velocity are best accounted for by postulating a resistance of about 150{Omega} cm2 separating the extracellular fluid from the lumen of the transverse tubules at the edge of the fibre, and a density of sodium channels in the tubular wall about a twentieth of that in the fibre surface.

3. Calculations with imposed voltage steps at the fibre surface suggest that the potential across the tubular membrane at the centre of the fibre is very far from clamped.

4. Currents providing charge for the tubular capacity can give rise to substantial errors in estimating the zero-current potential of the ionic currents.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 The Physiological Society.