HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bhoola, K. D. Articles by Jones, C. W. Search for Related Content PubMed PubMed Citation Articles by Bhoola, K. D. Articles by Jones, C. W.

1. The effect of age and androgen level on enzyme activity and cellular structure has been determined in the mouse submaxillary gland.

2. A new protease which resembles chymotrypsin in its substrate specificity has been characterized in the gland.

3. Activity of the chymotrypsin- and trypsin-like proteases and renin increased considerably in male mice concomitantly with proliferation of granules in the secretory tubules of the gland.

4. The androgen dependence of the chymotrypsin- and trypsin-like enzymes, renin and the organelles within the secretory tubules was confirmed in castrated male mice. The activity of these enzymes increased and correlated with the appearance of intracellular granules in the secretory tubules when the castrated male mice and in addition female mice were treated with testosterone preparations.

5. Kallikrein, a closely related protease, and amylase increased in activity with age but showed no sex-linked differences.

6. The results suggest that kallikrein is sequestered in acinar cells whereas the androgen-dependent enzymes (chymotrypsin, trypsin and renin) are located in the secretory tubules.