HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Astin, T. W. Articles by Warren, P. M. Search for Related Content PubMed PubMed Citation Articles by Astin, T. W. Articles by Warren, P. M.

1. In artificially ventilated open-chest cats and dogs ventilation with 5-15% CO₂ reversed the bronchoconstriction caused by drugs or by pulmonary artery occlusion. Total lung resistance, `static' lung compliance, and intratracheal or intrabronchial pressure at constant pump stroke were measured.

2. CO₂ reduced resistance and increased compliance of the lung during infusions of 5-hydroxytryptamine (5-HT), histamine and acetylcholine in cats. In dogs CO₂ reduced resistance during 5-HT infusions; it caused small reductions in intratracheal pressure but no significant change in resistance during infusions of histamine and acetylcholine. Even in cats CO₂ had a larger effect during 5-HT than during histamine and acetylcholine infusions.

3. Occlusion of a pulmonary artery caused increases in resistance and decreases in compliance in the affected lobes of both cats and dogs. These changes were partly reversed by ventilation with high CO₂ mixtures.

4. The bronchodilator action of CO₂ took place over a wide range of P_{a, CO2} values (20-100 torr).