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1. Plasma aldosterone concentrations have been measured by radio-immunoassay in the new-born and adult guinea-pig and related to plasma cortisol and corticosterone concentrations.

2. Plasma aldosterone concentrations were high in the hours immediately after birth with peak values of 552 pg/ml. at between 6 and 24 hr of age. Adult male plasma concentrations were 72 pg/ml. in plasma taken by cardiac puncture and 126 pg/ml. when measured in blood taken from an indwelling arterial catheter.

3. The major plasma glucocorticoid was cortisol and earlier reports of values above 1 µg/ml. were confirmed by more exacting column chromatography with Sephadex LH 20.

4. There was no constant relation between aldosterone and glucocorticoid concentrations in the animals studied, either new-born or adult.

5. Plasma cortisol: corticosterone ratios were not constant but varied considerably. In the adult a sevenfold rise in plasma cortisol concentration occurred under certain conditions without any change in plasma corticosterone concentrations.