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1. Changes in insensible perspiration and sweating were followed in normal subjects by continuously monitoring total body weight loss in environmental temperatures of 18, 29 and 37° C.

2. Pharmacological doses of ADH had no effect on cutaneous water loss at 18° C.

3. Pharmacological doses of ADH are capable of increasing the rate of cutaneous water loss in human subjects who are close to or above the thermal sweating threshold.

4. Physiological doses of ADH had no effect on cutaneous water loss in either cool or hot environments.

5. At normal rates of secretion in the body, ADH probably does not influence human sweat secretion.