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1. Four men, of ages varying from 23 to 28 years, living at Halley Bay, Antarctica (75° 31' S, 26° 39' W), were exposed to a mean air temperature of 6·6° C.

2. The concentration of serum triiodothyronine (T₃) rose significantly by the second day, remained raised, and returned to pre-exposure levels within 2 days of return to a normal environment.

3. The concentration of serum thyroxine (T₄) rose more slowly than did the T₃, reaching a maximum in 3-4 days and also returning to normal within 2 days of return to a normal environment.

4. There was a wide individual variation in the change of concentration of serum cortisol.

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