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1. As shown previously, slow muscle fibres of the frog develop the ability to produce action potentials in 2 weeks after denervation.

2. Normal transmission at the slow fibre neuromuscular junction gives a junction potential of 11 mV average (range 6-20 mV), caused by summation of potentials from several motor axons.

3. Botulinum toxin injected intramuscularly into the iliofibularis blocks the neuromuscular junction of slow fibres in 6 days at room temperature. Single nerve stimuli give junction potentials of 0·05 mV average (range 0-1·6 mV). Contraction of slow fibres in response to tetanic stimulation is eliminated.

4. No action potentials could be elicited in botulinum treated fibres, even 6 weeks after injection of toxin. This finding is discussed in relation to the possible involvement of a `trophic' factor regulating the action potential mechanism in frog slow muscle fibres.

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				J. A. Coffield, N. M. Bakry, A. B. Maksymowych, and L. L. Simpson Characterization of a Vertebrate Neuromuscular Junction That Demonstrates Selective Resistance to Botulinum Toxin J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1509 - 1516. [Abstract] [Full Text]