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1. Plasma renin (measured as rate of formation of angiotensin I ng/ml.hr-1 in the presence of added substrate at pH 7·5 and 37° C) was much lower in recently nephrectomized foetal, new-born and older lambs than in intact siblings or other similar lambs.
2. Angiotensin II-like concentrations were measured using a superfusion technique in an extracorporeal circuit. Resting concentrations in acute experiments under anaesthesia were deduced by comparison of carotid blood of intact lambs with that from recently nephrectomized lambs.
3. Angiotensin II-like activity (mean ± S.E. of mean, 315 ± 117 pg/ml.) was readily detectable in foetal blood at 123-138 days gestation. The highest concentrations (mean ± S.E. of mean 839 ± 96 pg/ml.) were found in lambs less than 8 hr old, delivered vaginally. The lowest concentrations of angiotensin II-like activity occurred in lambs delivered by Caesarean section (mean ± S.E. of mean < 123 ± 12 pg/ml.). Concentrations declined with post-natal age.
4. Hypovolaemia as a result of haemorrhage evoked an increase in angiotensin II-like concentrations in foetus, new-born lambs and adult sheep. The greatest increase of angiotensin-like concentrations was seen in new-born lambs. This rise was associated with increase of plasma renin.
5. The rise of arterial pressure during bilateral carotid occlusion in new-born lambs was accompanied by an increase of angiotensin II-like concentration.
6. It is concluded that the renin-angiotensin system is functional and can be stimulated during intra-uterine life. The increase of angiotensin II-like concentration following parturition is probably transient and associated with the trauma of delivery. This contrasts with observations made in the rabbit which suggest that full functional maturity of the renin angiotensin system is delayed until the second week of life.
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