HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morris, B. Articles by Morris, R. Search for Related Content PubMed PubMed Citation Articles by Morris, B. Articles by Morris, R.

1. ¹²⁵I-labelled homologous IgG was injected into different regions of the small intestine of rats aged 12, 16, 18, 20 and 22 days. At 12 days the proximal and middle regions of the intestine readily absorbed globulin and transmitted it to the circulation. The distal region of the intestine transmitted little to the circulation at all ages tested.

2. The intestine loses its ability to transmit globulin to the circulation in a distal-proximal direction. At 16 and 18 days the ability of the middle region had declined significantly, and this decline continued so that little globulin was transmitted from this region at 20 and 22 days.

3. The proximal intestine retained the ability to transmit globulin to the circulation in significant amounts up to 20 days.

4. There is a close negative correlation between body weight and total radioactivity of the sera of rats which had received doses of labelled globulin into the proximal and middle regions of the intestine. There was no such correlation after injection into the distal intestine — suggesting a restricted throughput of radioactive material by the absorptive cells of this region.

5. These results are discussed in the context of the termination of antibody absorption, and in relation to the results obtained using polyvinyl pyrrolidone.

This article has been cited by other articles:

				I. Stefaner, A. Praetor, and W. Hunziker Nonvectorial Surface Transport, Endocytosis via a Di-leucine-based Motif, and Bidirectional Transcytosis of Chimera Encoding the Cytosolic Tail of Rat FcRn Expressed in Madin-Darby Canine Kidney Cells J. Biol. Chem., March 26, 1999; 274(13): 8998 - 9005. [Abstract] [Full Text] [PDF]

				A Praetor, I Ellinger, and W Hunziker Intracellular traffic of the MHC class I-like IgG Fc receptor, FcRn, expressed in epithelial MDCK cells J. Cell Sci., January 7, 1999; 112(14): 2291 - 2299. [Abstract] [PDF]