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1. The efflux rate coefficients of sodium, potassium and chloride from immature oocytes of the toad Bufo bufo have been measured and found to be respectively, 0·0069, 0·0023 and 0·0034 min-1.
2. Replacement of external chloride by sulphate resulted in a fall in chloride efflux of about 50%. This has been interpreted in terms of exchange diffusion.
3. The membrane conductance has been measured and found to be 0·14 x 10-3 mhos cm-2 in good agreement with the value calculated from the flux data, 0·12 x 10-3 mhos cm-2, after taking account of the chloride exchange diffusion fraction.
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