J Physiol Boston Smyposia
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Physiol Vol 251, Issue 2 pp 287-301
Copyright © 1975 by The Physiological Society
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edwards, R H
Right arrow Articles by Jones, D A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edwards, R H
Right arrow Articles by Jones, D A

Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.

 R H Edwards, D K Hill and D A Jones

1. The biochemical basis of the slowing of relaxation seen in fatigue has been examined using an isolated mouse soleus preparation. 2. Slowing of relaxation occurred during prolonged tetani under anaerobic conditions when ATP and PC fell and lactate accumulated. 3. Slowing of relaxation was also demonstrated with muscles poisoned with cyanide and iodoacetic acid when there was a fall in ATP and PC but no accumulation of lactate. During a period of anaerobic recovery following a fatiguing tetanus, relaxation became faster at a time when lactate was accumulating in the muscle. 4. It is concluded that the slowing of relaxation in fatigue is not a consequence of lactate accumulation, and a relationship is demonstrated between the ATP content of the muscle and the rate of relaxation in muscles fatigued by prolonged stimulation, 5. Rates of ATP turn-over in fresh muscle, and at intervals throughout a tetanus are consistent with the suggestion that the rate limiting step for myofibrillar ATPase may be directly related to the rate limiting step for the decay of tension during relaxation.




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
D. G. Allen, G. D. Lamb, and H. Westerblad
Skeletal Muscle Fatigue: Cellular Mechanisms
Physiol Rev, January 1, 2008; 88(1): 287 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. A. Jones, C. J. de Ruiter, and A. de Haan
Change in contractile properties of human muscle in relationship to the loss of power and slowing of relaxation seen with fatigue
J. Physiol., November 1, 2006; 576(3): 913 - 922.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. Lee Clark and S. E. Peters
Isometric contractile properties of sexually dimorphic forelimb muscles in the marine toad Bufo marinus Linnaeus 1758: functional analysis and implications for amplexus
J. Exp. Biol., September 1, 2006; 209(17): 3448 - 3456.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. B. Lopes-Martins, R. L. Marcos, P. S. Leonardo, A. C. Prianti Jr., M. N. Muscara, F. Aimbire, L. Frigo, V. V. Iversen, and J. M. Bjordal
Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in rats
J Appl Physiol, July 1, 2006; 101(1): 283 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. E. Kan, T. E. Buse-Pot, R. Peco, D. Isbrandt, A. Heerschap, and A. de Haan
Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C113 - C119.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. R. Hancock, E. Janssen, and R. L. Terjung
Skeletal muscle contractile performance and ADP accumulation in adenylate kinase-deficient mice
Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1287 - C1297.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. M. Rijkelijkhuizen, C. J. de Ruiter, P. A. Huijing, and A. de Haan
Low-frequency fatigue, post-tetanic potentiation and their interaction at different muscle lengths following eccentric exercise
J. Exp. Biol., January 1, 2005; 208(1): 55 - 63.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. L Dutka and G. D Lamb
Effect of low cytoplasmic [ATP] on excitation-contraction coupling in fast-twitch muscle fibres of the rat
J. Physiol., October 15, 2004; 560(2): 451 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Gorselink, M. R. Drost, K. F. J. de Brouwer, G. Schaart, G. P. J. van Kranenburg, T. H. M. Roemen, M. van Bilsen, M. J. Charron, and G. J. van der Vusse
Increased muscle fatigability in GLUT-4-deficient mice
Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E348 - E354.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Gorselink, M. R. Drost, W. A. Coumans, G. P. J. van Kranenburg, R. P. Hesselink, and G. J. van der Vusse
Impaired muscular contractile performance and adenine nucleotide handling in creatine kinase-deficient mice
Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E619 - E625.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. K. Vollestad, I. Sejersted, and E. Saugen
Mechanical behavior of skeletal muscle during intermittent voluntary isometric contractions in humans
J Appl Physiol, November 1, 1997; 83(5): 1557 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Shields, L. F. Law, B. Reiling, K. Sass, and J. Wilwert
Effects of electrically induced fatigue on the twitch and tetanus of paralyzed soleus muscle in humans
J Appl Physiol, May 1, 1997; 82(5): 1499 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 Neurorehabil Neural RepairHome page
J. A. Kent-Braun, K. R. Sharma, R. G. Miller, and M. W. Weiner
Effects of Electrically Stimulated Exercise Training on Muscle Function in Multiple Sclerosis
Neurorehabil Neural Repair, January 1, 1996; 10(3): 143 - 151.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 The Physiological Society.