HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hull, K L Articles by Roses, A D Search for Related Content PubMed PubMed Citation Articles by Hull, K L, Jr Articles by Roses, A D

1. 22Na and 42K radioisotopes were used to measure Na efflux and K influx in identical suspensions of fresh erythrocytes from myotonic dystrophy patients and matched controls under the same conditions and in the same time interval. K was present in concentration 10 mM in the suspending medium to prevent Na-for-Na exchange. Each flux was measured in the presence and absence of ouabain. The mean ouabain-sensitive Na efflux rate in controls (2-33+/-0-13, S.E. of mean, m-equiv/1. cells.hr) was significantly greater (P less than 0-001) than the corresponding rate in myotonic dystrophy (1-64+/-0-09). 2. No significant differences between myotonic dystrophy and controls in mean ouabain-insensitive Na efflux, mean ouabain-sensitive K influx, or mean ouabain-insensitive K influx were found. 3. The stoichiometric ratio (ouabain-sensitive Na efflux)/(ouabain-sensitive K influx) was determined for each flux experiment. The mean stoichiometric ratio determined in controls (1-46+/-0-08) reconfirms extensive previous evidence favouring a 3Na-for-2K active exchange in controls. 4. The mean stoichiometric ratio determined in myotonic dystrophy (1-01+/-0-06) is statistically significantly different (P less than 0-001) from that in controls. These findings are interpreted as indication of 2Na-for-2K exchange in erythrocytes from patients with myotonic dystrophy.

This article has been cited by other articles:

				J. D. Rhodes, D. G. Monckton, J. P. McAbney, A. R. Prescott, and G. Duncan Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility Hum. Mol. Genet., December 15, 2006; 15(24): 3559 - 3568. [Abstract] [Full Text] [PDF]

				G. Sarpel, H. J. Lubansky, M. J. Danon, and A. Omachi Erythrocytes in Muscular Dystrophy: Investigation With 31P Nuclear Magnetic Resonance Spectroscopy Arch Neurol, May 1, 1981; 38(5): 271 - 274. [Abstract] [PDF]