J Physiol Boston Smyposia
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J Physiol Vol 254, Issue 3 pp 711-727
Copyright © 1976 by The Physiological Society
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Relationship between initial chemical reactions and oxidative recovery metabolism for single isometric contractions of frog sartorius at 0 degrees C.

 M J Kushmerick and R J Paul

1. Measurements of intitial chemical changes and recovery oxygen consumption (deltaO2) were made in unpoisoned aerobic frog sartorius muscles at 0 degrees C to provide independent measures of the chemical energy used for isometric tetani of various durations. 2. DeltaO2 was measured polarographically and increased in a curvilinear fashion with stimulus duration. For stimulations longer than 4 sec deltaO2 was a linear function of the tension-time integral. 3. Measurements of the changes in the content of phosphorylcreatine, 'free' creatine and inorganic phosphate were made in muscles rapidly frozen during a tetanus. The average of these quantities, delta approximately P, was used to measure the initial 'high energy' phosphate utilization. No break-down of 'high-energy' phosphate compounds was detected up to 200 sec after relaxation of tension. Changes in the content of ATP were not observed except for a small decrease (-0-25+/-0-1 mumole/g) in muscles tetanized for 1 sec. 4. Delta approximately P also increase curvilinearly with tetanus duration and, for tetanic durations greater than 4 sec, was a linear function of the tension-time integral. 5. Both deltaO2 and delta approximately P were quantitatively related by a constant scaling factor of about 4-3 (delta approximately P/deltaO2) throughout the range of tetanic durations studied. The constancy of this ratio.provides evidence against the hypothesis that a significant 'missing reaction' provides energy during any one portion of the tetanus. Several hypothesis may account for the numerical value of the ration delta approximately P/deltaO2.




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