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Department of Physiology, University College, London W.C.1

1. Ventriculo-cisternal perfusions were performed on rabbits with artificial cerebrospinal fluid containing blue dextran and tritium-labelled prostaglandin F₂ ([³H]PGF₂). In order to study the nature of prostaglandin (PG) transfer across the blood—brain barrier, high concentrations of PGF₂ or potential PG transport inhibitors were added to the perfusion fluid after the normal rate of [³H]PGF₂ clearance was established.

2. The [³H]PGF₂ clearance was inhibited by 10^-6 to 10^-3M PGF₂, PGF₂, probenecid, iodipamide or bromcresol green but not by perchlorate.

3. The ³H content of the brain, relative to the ³H-activity in the ventricular system, was also increased by high concentrations of PGF₂, iodipamide or bromcresol green.

4. It is concluded that the removal of PGs from the extracellular fluids of the brain is mediated by saturable, facilitated transport processes across both the choroidal and extrachoroidal regions of the blood—brain barrier system. In the case of the mammalian brain, such facilitated PG transport appears to be the primary mechanism for the termination of the action of these potent, endogenously produced autacoids.

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				H. A. Gross, D. L. Dunner, D. Lafleur, H. L. Meltzer, H. L. Muhlbauer, and R. R. Fieve Prostaglandins: A Review of Neurophysiology and Psychiatric Implications Arch Gen Psychiatry, October 1, 1977; 34(10): 1189 - 1196. [Abstract] [PDF]