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J Physiol Vol 267, Issue 1 pp 249-260
Copyright © 1977 by The Physiological Society
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Chemical energetics in repeated contractions of frog sartorius muscle at 0° C

 M. J. Kushmerick and R. J. Paul*

Department of Physiology, Harvard Medical School, 25 Shattuck Street, Boston, Mass. 02115, U.S.A.

1. Recovery oxygen consumption ({Delta}O2) was measured in aerobic, unpoisoned frog sartorius muscles at 0° C following a series of repeated tetani.

2. For a series of tetani having nearly identical tension—time integrals, {Delta}O2 was dependent on the interval between tetani and reached a maximal value for intervals equal to or greater than 200 sec.

3. For a series of tetani at short (5 sec) intervals, {Delta}O2 was not distinguishable from {Delta}O2 following a single long tetanus having a tension-time integral similar to that of the sum of the series.

4. A model is proposed to account for these observations in terms of the initial chemical reactions ({Delta} ~ P) including a saturable non-steady state reaction which utilizes about 1 µmole {Delta} ~ P/g and which is superimposed on an energy utilization proportional to the tension—time integral. Measurements of {Delta}O2 and {Delta} ~ P as functions of tetanic duration and interval between tetani are consistent with such a model.

5. These experiments show that, in addition to parameters usually considered, the previous contractile history of a muscle plays a significant role in determining the chemical energy cost of an isometric contraction.

* Present address: Department of Physiology, University College London, Gower Street, London WC1E 6BT.




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