J Physiol Boston Smyposia
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J Physiol Vol 267, Issue 3 pp 659-666
Copyright © 1977 by The Physiological Society
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Endogenous pyrogen-like substance produced by reptiles.

H A Bernheim and M J Kluger

1. Injection of lizards (Dipsosaurus dorsalis) with rabbit endogenous pyrogen led to a fever. Injections with denatured endogenous pyrogen did not affect body temperature. 2. Injection of lizards with lizard endogenous pyrogen led to a fever of short duration, while injection of denatured lizard endogenous pyrogen produced no change in body temperature. 3. These data support the hypothesis that the febrile mechanism observed in the higher vertebrates has its origins in some primitive vertebrate.







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