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1. The objective was to find out what kind of informatioon regarding systemic blood pressure is transduced by baroreceptors in vivo and how this information is coded in the receptor discharge. 2. Carotid sinus pressure, e.c.g., and receptor action potentials were recorded for fifty-two single fibre carotid sinus receptors found in twenty decerebrated unanaesthetized cats. 3. The inflation and gradual deflation of an intraaortic catheter tip balloon manipulated the blood pressure in the carotid sinus in a way as to define the full in vivo stimulus-response curve for each receptor. 4. Correlation coefficients were computed between stimulus and response variables for several points on the response curve of each receptor and for every possible combination of stimulus and response variables defined. 5. Stimulus variables were (a) systolic, (b) diastolic,, (c) mean, (d) pulse pressures and (e) peak positive dP/dt. Response variables were (a) average discharge rat, (b) peak instantaneous frequency, and (c) average burst frequency. 6. For every fibre in the sample only the correlations between systolic, diastolic and mean pressures vs. average discharge rate were consistently high and positive. All other correlations were numerically low and/or negative. 7. It was concluded that in vivo baroreceptors signal mainly pressure level (systolic, diastolic or mean) as opposed to pulse pressure or dP/dt, and that the average discharge rate is their best index of information content.