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1. We have measured the relationship between tidal volume (V_T) and the duration of inspiration (T_i) and expiration (T_e) for individual breaths (30 in each steady state).

2. Ten pre-term and ten term infants were studied during steady state while breathing 21% O₂, then 21% O₂ plus 2 and 4% CO₂.

3. In all infants, the average T_i at the various chemical drives was remarkably constant, and did not decrease as the tidal volume increased. However, at any given level of respiratory drive, there was a slightly positive correlation of V_T with T_i and T_e in 95% of the cases.

4. In four pre-term and two term infants, T_e increased with increasing respiratory drive. In these infants, therefore, instantaneous respiratory frequency (1/(T_i + T_e)) actually decreased as lung volume increased.

5. We suggest that T_i is independent of V_T within the range of volumes studied (up to 2 times the resting V_T) and that changes in instantaneous respiratory frequency (1/(T_i + T_e)) result from changes in T_e.

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				P. S. Rabbette and J. Stocks Influence of volume dependency and timing of airway occlusions on the Hering-Breuer reflex in infants J Appl Physiol, December 1, 1998; 85(6): 2033 - 2039. [Abstract] [Full Text] [PDF]