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1. Ambiguities and discrepancies in the published descriptions of the patterns of breathing in man have been re-investigated.

Steady-state hyperpnoea during rest was induced in normal subjects of both sexes by means of CO₂ inhalation, usually in high O₂, but sometimes in low (P_{A, O2} 200 and 55 torr respectively).

2. The relations between mean tidal volume _T and mean times for inspiration _I and expiration _E were satisfactorily divided into lower and upper parts (ranges 1 and 2) in nineteen out of thirty-three experiments using an objective least-squares method, and polynomials were fitted separately to each of the following pairs of variables _T,lower, _I; _T,lower, _E; _T,upper, _I; _T,upper, _E.

3. The breakpoints occurred when _T was about one third of vital capacity, but there was much variation between subjects.

4. In range 2, _T was inversely related to both _I and _E and there appeared to be linkage between _I and _E, all as described by Clark & Euler (1972). The relation suggested by Hey, Lloyd, Cunningham, Jukes & Bolton (1966) over range 2 was not confirmed.

5. The main part of the relation described by Hey et al. (1966) is concerned with range 1. Here the relation between _T and _I was variable; slight, but significant negative correlation predominated. _T was, on the other hand, strongly and inversely related to _E, and plots of (_E — _I) against _T over both ranges showed even less scatter. Hence (a) _E is probably related to _T through two mechanisms, one involving a link with T_I and another prominent one being quite independent of T_I, (b) most changes of respiratory frequency in normal man are brought about by change of T_E rather than of T_I, and (c) there is no region of constant frequency as implied by Clark & Euler (1972).

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