HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Barker, G R Articles by Roberts, S K Search for Related Content PubMed PubMed Citation Articles by Barker, G R Articles by Roberts, S K

1. Five subjects took 210 test meals of 750 ml. water containing 30--300 m-molal glucose or glycine, or 15--150 m-molal diglycine, or plain water. 2. The greater the concentration of solute, the greater was the volume of original meal recovered from the stomach after a fixed time. 3. On a molal basis glucose was half as effective as diglycine in slowing gastric emptying. This was consistent with the osmoreceptor being exposed to the diglycine after it had been split by the hydrolase of the cytosol of enterocytes (the absorbing cells of the small intestine). 4. The slowing of gastric emptying (ml./mole.1.) was about 10% greater for glycine than it was for glucose. There was apparently a threshold concentration below which glycine did not slow gastric emptying. 5. It was proposed that the response of the doudenal osmoreceptor might depend upon shrinking and swelling of the lateral intercellular space around the enterocytes.

This article has been cited by other articles:

				R. J. Maughan, J. B. Leiper, and G. E. Vist Gastric emptying and fluid availability after ingestion of glucose and soy protein hydrolysate solutions in man Exp Physiol, January 1, 2004; 89(1): 101 - 108. [Abstract] [Full Text] [PDF]

				J T McLaughlin, L E A Troncon, J Barlow, L J Heggie, and D G Thompson Evidence for a lipid specific effect in nutrient induced human proximal gastric relaxation Gut, August 1, 1998; 43(2): 248 - 251. [Abstract] [Full Text] [PDF]