HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Clarke, G D Articles by Davison, J S Search for Related Content PubMed PubMed Citation Articles by Clarke, G D Articles by Davison, J S

1. Electrical stimulation of the abdominal vagi revealed that abdominal vagal fibres are distributed throughout the cervical vagal trunk. Conduction velocities of the main group of abdominal fibres ranged from 0.4 to 1.5 m.sec-1. 2. Thirty-seven single afferent fibres, with endings in the gastric and intestinal mucosa, were isolated from the cervical vagus of adult rats. Conduction velocities of eighteen of these endings ranged from 0.5 to 2.5 m.sec-1. 3. Light mechanical stimulation, such as stroking the mucosa, evoked a rapidly adapting response from these endings. Sustained pressure or distension with fluid or air did not excite these endings although excessive stretching of the mucosa excited three units. Balloon distension usually evoked an 'on-off' response due to phasic stimulation of the mucosa by the balloon during inflation and deflation. 4. These same endings also functioned as non-specific, slowly adapting chemoreceptors responding to various organic and inorganic acids, tap water and distilled water, alcohol, hypertonic saline, NaOH, NH4Cl, CuSO4, casein hydrolysate, mustard powder and cayenne pepper. Hypertonic glucose and guinea-pig bile were ineffective as stimuli. 5. In the presence of an excess of chloride ions the effectiveness of acids in stimulating these endings was in part determined by the pK of the acid. However pH per se was not the basic determining factor but rather the molecular size of the acid.

This article has been cited by other articles:

				D. W. Adelson, H. P. Kosoyan, Y. Wang, J. Z. Steinberg, and Y. Tache Gastric Vagal Efferent Inhibition Evoked by Intravenous CRF Is Unrelated to Simultaneously Recorded Vagal Afferent Activity in Urethane-Anesthetized Rats J Neurophysiol, April 1, 2007; 97(4): 3004 - 3014. [Abstract] [Full Text] [PDF]

				M. Danzer, M. Jocic, C. Samberger, E. Painsipp, E. Bock, M.-A. Pabst, K. Crailsheim, R. Schicho, I. T. Lippe, and P. Holzer Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G403 - G411. [Abstract] [Full Text] [PDF]

				A. J. Page, C. M. Martin, and L. A. Blackshaw Vagal Mechanoreceptors and Chemoreceptors in Mouse Stomach and Esophagus J Neurophysiol, April 1, 2002; 87(4): 2095 - 2103. [Abstract] [Full Text] [PDF]

				H.-R. Berthoud, P. A. Lynn, and L. A. Blackshaw Vagal and spinal mechanosensors in the rat stomach and colon have multiple receptive fields Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1371 - R1381. [Abstract] [Full Text] [PDF]

				Y.-X. Lu and C. Owyang Duodenal acid-induced gastric relaxation is mediated by multiple pathways Am J Physiol Gastrointest Liver Physiol, June 1, 1999; 276(6): G1501 - G1506. [Abstract] [Full Text] [PDF]

				X. Zhang, W. E. Renehan, and R. Fogel Neurons in the vagal complex of the rat respond to mechanical and chemical stimulation of the GI tract Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G331 - G341. [Abstract] [Full Text] [PDF]