HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnston, D Search for Related Content PubMed PubMed Citation Articles by Johnston, D

1. The slow outward current in Aplysia burst-firing neurones was studied under voltage-clamp conditions. This current, designated Iso, was measured as the incremental outward tail current following small depolarizing commands. 2. Iso was shown to be a pure K+ current, probably activated by the influx of Ca2+ during the depolarizing command (Johnston, 1976). For small depolarizations, the peak conductance was about 10(-7) mhos. 3. The rate of decay of Iso could be fit by a single exponential and was voltage-dependent, increasing with depolarization. 4. The decay rate of Iso was also temperature-dependent, with a Q10 of about 3. The peak conductance, however, was much less temperature-sensitive, with a Q10 of about 1.5. 5. The voltage dependence of decay rate suggested either the presence of a voltage-dependent Ca2+ pump or that the change in intracellular calcium concentration was not the rate-limiting step in the decay of Iso.

This article has been cited by other articles:

				D. A. Baxter, C. C. Canavier, J. W. Clark Jr., and J. H. Byrne Computational Model of the Serotonergic Modulation of Sensory Neurons in Aplysia J Neurophysiol, December 1, 1999; 82(6): 2914 - 2935. [Abstract] [Full Text] [PDF]