HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grinwald, P M Articles by Segal, M B Search for Related Content PubMed PubMed Citation Articles by Grinwald, P M Articles by Segal, M B

1. When the heart is deprived of substrate and O2 for a long period, the ATP content falls to very low levels, with associated changes in ADP and AMP content, and a fall in intracellular pH. 2. These changes appear sufficient to block the hexokinase reaction, outweighing the normal mechanisms controlling this enzyme. Anaerobic glycolysis then remains blocked, even when glucose supply is restored. The block in anaerobic glycolysis can be overcome, however, by a brief period of oxidative metabolism, apparently because the improvement in adenine nucleotide levels serves to 're-prime' the system. 3. When the cell is severely depleted of ATP, the resulting impairment of glycolysis tends to reinforce the low ATP content, establishing a vicious cycle. Metabolic effects of this kind may cause irreversible loss of function, and may contribute to the mechanism of cell death.

This article has been cited by other articles:

				Z. Zou, S. Sasaguri, K. G. Rajesh, and R. Suzuki dl-3-Hydroxybutyrate administration prevents myocardial damage after coronary occlusion in rat hearts Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1968 - H1974. [Abstract] [Full Text] [PDF]

				K. W. Park, H. B. Dai, M. E. Comunale, A. Gopal, and F. W. Sellke Dilation by Isoflurane of Preconstricted, Very Small Arterioles from Human Right Atrium Is Mediated in Part by K+-ATP Channel Opening Anesth. Analg., July 1, 2000; 91(1): 76 - 81. [Abstract] [Full Text] [PDF]